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cGMP, in turn, activates cGMP-dependent protein kinase resulting in membrane hyperpolarization and subsequent vasodilatation

The IL-6 transmits inflammatory-related information via IL-6 receptor and glycoprotein 130 (gp 130) that makes a specific receptor complex that causes gp130-associated Janus kinases (Jak) to become activated, and results in the phosphorylation of tyrosine residues within the cytoplasmic part of gp130 serve as binding sites for the transcription factor STAT3, JAKs and phosphorylated STAT3-dimers phosphorylate these translocate into the nucleus to induce STAT-specific gene expression