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Phase 1-2a multicenter dose-ranging study of canfosfamide in combination with carboplatin and paclitaxel as first-line therapy for patients with advanced non-small cell lung cancer
thaliana ecotype C-24 resistant to the yellow strain of Cucumber mosaic virus (CMV Y) was coupled to elevated induction of a GST gene (Ishihara et al., GST genes were among the most highly up-regulated defense-related sequences identified in a line resistant to Capsicum chlorosis virus (CaCV) at the time point when lesions were fully developed (Widana Gamage et al., Importantly, the above results imply that certain GST isoenzymes are not only antioxidants but also have a role in the establishment and/or signaling of virus resistance
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For the colorectal cancer PDX study, female NCR nude mice (CrTac:NCr- Foxn1 nu from Taconic) were implanted subcutaneously with low-passage KRAS-mutant CRM 13180 tumour fragments (30 mg) into the region of the right axilla
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