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IC 50 values were calculated using GraphPad Prism 8 (RRID: SCR_002798)

without NDR = 261) in each SEM conforms to the guidelines regarding the minimum sample size of 200, 10 observations per estimated parameter and 10 cases per variable as discussed in recent studies using Monte Carlo data simulation techniques to evaluate sample size requirements for SEM [67]

Indeed, pathways of regulated cell death including apoptosis and necrosis have emerged as central events in the pathogenesis of various kidney diseases that may be amenable to therapeutic intervention

The 1-adrenergic receptors, found on the surface of cells, facilitate various physiological responses, including regulating vascular contraction and heart rate