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TB-500: G-actin, cell migration and differentiation TB-500 operates through a completely different mechanism: Monomeric G-actin sequestration : maintains a free actin pool mobilizable for migration of repair cells (stem cells, fibroblasts, endothelial cells) Modulation of cell differentiation : publications have suggested effects on myocardial, neural and vascular differentiation Anti-fibrotic and anti-inflammatory effects (NF-B inhibition, cytokine modulation) Documented strengths: cardiac recovery post-ischemia, cutaneous healing, extracellular matrix remodeling, deep muscle recovery