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Assess whether educational content avoids dosing, reconstitution, calculator-output interpretation, and administration guidance

Combination of sorafenib and arsenic trioxide exerts synergistic anti-leukemia effects in sorafenib-resistant FLT3-ITD-harboring AML cells

Heffernan MA, Thorburn AW, Fam B, et al

Sorafenib induces ferroptosis by targeting the cystine/glutamate anti-transport system Xc- [154,155,156,157], an effect that impinges on cystine uptake, thereby preventing subsequent synthesis of glutathione (GSH), the major intracellular antioxidant, preventing GPX4 activation [158, 159], and can trigger ER stress and ferroptosis