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IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Proc Natl Acad Sci U S A 115(46):E10849E10858

Functional recovery ultimately most important outcome though must balance testing against re-injury risk

This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)