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In addition to direct antioxidant responses, it has also been shown that bilirubin can indirectly function to the alleviation of oxidative stress, examples including activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through covalently binding to Kelch-like ECH-associated protein 1 (KEAP1) (54, 61) and thus acting as an antioxidant in the cell

The peptide achieves 60% reduction in ROS levels in WI-38 cells pretreated with 10 nM-10 M GHK-Cu then exposed to 150 M hydrogen peroxide

Thosar et al., 2018), and includes heart rate and heart rate variability (Massin et al., 2000), sympathetic tone (Panza et al., 1991), blood pressure (Coca, 1994), and cerebral blood flow (Conroy et al., 2005

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