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Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials

Long-Term Considerations While clinical trials up to 24 weeks demonstrate excellent safety, data on continuous use beyond 6-12 months remains limited

In developed countries, situations at greatest risk for deficiency include eating a diet restricted in fruits and vegetables, smoking or long-term exposure to secondhand smoke, and drug and alcohol abuse