They include Russias strategy of using negotiations as a fig leaf for securing its maximalist objectives, all the way to de facto ending Ukraines existence as an independent state, and Ukrainian President Volodymyr Zelenskys refusal to cede the remainder of Donetsk
Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
Anecdotal reports suggest tolerance over extended periods, but unknown risks remain
Brain Research Bulletin, 176, 139-146