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[iv] Finally, a number of additional factors may influence the design of first-in-human clinical trials, including the presence or absence of biomarkers, the suitability of the selected preclinical models, and the demographic characteristics of the study participants

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The mRNA level of asparagine synthetase ( ASNS ), which plays roles in protein synthesis, was significantly decreased in the L-carnitine group in the fasting state, both the liver and muscle (Fig