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Likewise, the immune cells infiltrated in the tumor microenvironment such as cytotoxic T cells and natural killer (NK) cells, rather showing tumoricidal activity, feed into the tumor associated inflammation (Zou, 2005)

Fereidan-Esfahani and Tobin 2021)

Despite extensive preclinical support, clinical trials of these agents have yielded largely inconsistent and disappointing outcomes (summarized in Table 1), highlighting fundamental translational challenges