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Version 6.3 (updated 2022)

To exemplify, aripiprazole and risperidone have proven useful for controlling irritability, aggression and emotional dysregulation, compared to placebo (Salazar, et al., 2023)

Tolerance occurring due to a downregulation of D2 receptors has been identified in human and animal studies, and withdrawal has been apparent in animal studies, e.g., observed tremor, signs of depression, and increased corticotropin-releasing factor (CRF) (99)