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Sultana Z, Maiti K, Aitken J, Morris J, Dedman L, Smith R

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3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

Further evidence for this comes from the knowledge that GSTP can selectively inhibit C -Jun phosphorylation by JNK, preventing apoptosis