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The oxidative stress gene polymorphisms may affect the disease, independently of the type, although there is a high data variability due to the difference in genotype frequency among ethnicities and the possibility of functional compensation by other genes

The prognosis for people with this type varies with disease stage and is typically poorer than with other melanoma subtypes

Contraindications: Hypersensitivity Side Effects: CNS Depression (Sedation) & Bradycardia : The most common adverse effects of clonidine are sedation, dry mouth (xerostomia) , fatigue , bradycardia , dizziness, and constipation (Patel and Saadabadi, 2025