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Common eligibility BMI of 40+, or BMI 3539.9 with significant obesity-related conditions (type 2 diabetes, hypertension, sleep apnoea), which aligns with how overweight for gastric bypass is typically assessed in specialist clinics Previous non-surgical weight loss attempts without lasting results Understanding of lifelong dietary changes and supplementation required Agreement to long-term follow-up Medically fit for general anaesthesia Factors affecting candidacy Smoking: most programmes require stopping 48 weeks before surgery Uncontrolled conditions: diabetes, heart disease, or psychiatric disorders may need stabilising first

Direct comparisons are not available yet, and Phase 3 retatrutide results will land after CagriSema has already filed for approval

Regular stress management practices (meditation, deep breathing, exercise, adequate social connection) reduce mast cell hyperactivation through neuroimmune pathways

Another study investigates the therapeutic effectiveness of apricot kernel extract (AKE) in alleviating dry eye symptoms following lacrimal gland excision in an animal model