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doi: 10.1016/j.cell.2015.04.041

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A 2026 UK review of the nicotineBDNF7 nAChR plasticity link, the adolescent-brain risk, the 2025 cerebrovascular study, the HGF/c-Met synaptogenesis case and why quitting nicotine, not a peptide, clears vape brain fog Read the full review Substance & Lifestyle Neuroscience 14 June 2026 Dihexa for Cannabis & Weed Brain Fog: THC, Working Memory & the 2026 UK Review Why is my head so foggy when I smoke and why wont it clear now Ive stopped? Cannabis is Britains most-used illicit drug, and in January 2025 the largest brain-imaging study of its kind ( JAMA Network Open , 1,003 adults) found most heavy and recent users showed reduced brain activity during a working-memory task