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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig
The family of drugs that inhibit mTOR, such as rapamycin, temsirolimus, metformin, everolimus, and deforolimus, are already known to activate autophagy and are efficient in the treatment of age-related neurodegenerative diseases, such as Alzheimers, Parkinsons, and Huntingtons diseases [83]
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