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It interacts with the pro-apoptotic protein Bax, inhibiting its translocation to the mitochondria and preventing the release of cytochrome c (Hashimoto et al., 2001)

The incidence of these side effects tends to decrease with continued use and proper dose titration

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Many post-traumatic brain injuries present with significant neurovascular flow changes, which is why our approach of transcranial doppler ultrasound blood-brain barrier imaging of cerebral vessels can help directly visualize and measure perfusion and flow problems non-invasively in many cerebrovascular brain disorders (3a) including traumatic brain injury, stroke, vasospasm, micro-emboli, atherosclerosis, headaches, Alzheimers disease, dementia, and others