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Because they stimulate the endogenous (natural) production of GH rather than injecting synthetic, exogenous GH directly, they preserve the natural negative feedback loop of the body

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doi: 10.1016/j.bcp.2022.114989 201 RidnourLAChengRYKedeiNSomasundaramVBhattacharyyaDDBasudharDet al

GHRP-6 - Growth Hormone Release & Appetite Signaling Stimulates endogenous growth hormone pulses Activates GHIGF signaling cascade Engages hunger-related pathways Mimics physiological GH rhythm Influences downstream anabolic signaling Targets GHS-R1a pathways Influences energy balance networks Supports tissue repair signaling Description GHRP-6 is a synthetic growth hormone releasing peptide belonging to the ghrelin mimetic family