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Two examples are the impairment of clathrin-mediated endocytosis and of nuclear protein degradation, due to polyQ-mediated sequestration of the highly abundant major chaperone heat shock cognate protein 70 (HSC70) and of a low-abundance cochaperone, Sis1p/DNAJB1, respectively [64, 65]

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The Panama Clinics pediatric waiting areas use soft indirect lighting and interactive elements