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It may be considered by a GP or specialist in specific clinical scenarios, such as: Supporting assessment of metabolic syndrome in individuals with central obesity, dyslipidaemia, or hypertension, where it may provide additional context alongside glucose-based tests Investigating possible insulin resistance in people with polycystic ovary syndrome (PCOS) noting that PCOS diagnosis does not require fasting insulin, and NICE CKS recommends OGTT or fasting plasma glucose when assessing glycaemic risk in this group Evaluating unexplained hypoglycaemia , where inappropriately elevated insulin levels may suggest insulinoma or another cause of endogenous hyperinsulinism however, a formal supervised fast measuring insulin, C-peptide, proinsulin, and a sulfonylurea screen is required for this investigation, and endocrinology referral is essential Supporting clinical decisions in specialist endocrinology or obesity medicine settings Patients seeking fasting insulin testing outside these indications are likely to need to access it through private healthcare providers
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doi:10.3390/nu11051056
