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However, prolonged oral administration for 6 weeks does not promote growth and abolishes the GH stimulatory effect of MK-677, potentially resulting from increased expression of SST in the hypothalamus

This triple agonist design, developed by Eli Lilly under the research code LY3437943, represents a fundamentally different approach from semaglutide (which targets only GLP-1) or tirzepatide (which targets GLP-1 and GIP)

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