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These pathways include the regulation of the tricarboxylic acid (TCA) cycle, aerobic glycolysis and fatty acid (FA) synthesis, which are crucial for tumour cell survival and proliferation (30,31) and also affect the stromal and immune cell components of the tumour microenvironment (32)

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Nonetheless, the inability of OPCs to differentiate into mature oligodendrocytes in the aged brain is not currently debated, and it likely contributes to the reduced capacity for remyelination and declining oligodendrocyte population (Sim et al., 2002

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