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Interestingly, this P R RA R insertion generates a furin cleavage site on S-protein at the S1/S2 multi-basic region, considered as a potential gain of function for the viral pathogen

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Its levels vary throughout the body, reaching up to 10 mM in liver cells while other cells maintain millimolar concentrations

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease