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In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy
FIGURE 8-6 Schematic of a tight junction at the blood-brain barrier (BBB)
The results demonstrate that DSIP significantly accelerates the recovery of motor function, although its effect on brain infarct volume did not reach statistical significance
Insbesondere fr Multimorbiditt gibt es zunehmend Evidenz, dass ein bidirektionaler Zusammenhang vorliegt: Fr Patienten und Patientinnen mit Multimorbiditt ist das Risiko einer depressiven Erkrankung erhht, ebenso ist fr Patientinnen und Patienten mit einer depressiven Erkrankung das Risiko fr Multimorbiditt erhht
