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The researchers reported that administering the peptide to mice reduced CGRP-induced plasma protein extravasation (PPE), indicating the antagonistic effects of the peptide in vivo

Oregon R + was used as the wild type control line for all experiments

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The impact of modified nucleosides on mRNA immunogenicity and their use in mRNA-based therapy The efficacy and prospects of using mRNA vaccines for the treatment of various diseases depend, among other factors, on the immunological properties of the formulation, specifically its immunogenicity and reactogenicity