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PMID: 113 WangY.ZhaoM.ZhaoL.GengY.LiG.ChenL.et al

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Ferroptosis describes a form of regulated cell death that is driven by unrestricted lipid peroxidation, which does not require the activation of caspase and can be suppressed by iron chelators, lipophilic antioxidants, inhibitors of lipid peroxidation, and depletion of polyunsaturated fatty acids (PUFAs) [6, 7]

they frequently lack appropriate specificity, chemical stability, or interference resistance to cellular components [115] and they are mostly incapable of simultaneously quantifying the intricate network of interconnected redox couples (e.g., GSH/GSSG, NAD/NADH, and Trx redox states) with adequate sensitivity under physiologically relevant conditions [116]