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Aged mice also have hallmarks of BBB breakdown compared to young mice with increased leakage of IgG into the brain parenchyma, a reduction of the tight junction protein occludin, and a reduction in pericyte coverage and pericyte induced expression of genes in the endothelium [54, 90, 91]

From there, the peptide circulates throughout the body, reaching joints, tendons, and nerves that need repair

162 The above studies indicate that AMPs can also be used as chemotherapeutic drug sensitizers, and the combination of AMPs and chemotherapeutic drugs has broad application prospects in the treatment of multidrug-resistant tumors