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Changes in R g and R h can reflect aggregation or conformational changes, and evaluating the shape factor under different conditions can be used for the analysis of protein stability and folding status

Putzeys and Jeanne Brosteaux (Putzeys and Brosteaux, 1935), and in 1941 these authors reported the M w values for more than 20 proteins (Putzeys and Brosteaux, 1941)

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