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As examples, emerging evidence links increased G6PD activity and PPP flux to hyper-functional dendritic cells in aplastic anemia (109), as well as pro-inflammatory activated T cells in rheumatoid arthritis (110)

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Administration of high-fat diets to promote atherosclerosis in animal models is a valuable tool for studying pathogenesis and testing novel compounds for treatment or prevention of atherosclerosis (Namazi et al., 2018)

MGF and Cardiac Preservation Research Systemic delivery of the MGF E-domain peptide at the time of myocardial infarction in mice resulted in significant preservation of cardiac contractility at 2 weeks post-MI, with an inhibition of pathological hypertrophy and significantly fewer apoptotic nuclei in the viable myocardium of E-peptide-treated mice compared to untreated controls establishing the E-domain as the biologically active region responsible for cardioprotective effects