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The medication will typically be started at a low dose and gradually titrated to minimize side effects while optimizing efficacy

Dangers and uncertainties still loom

The concept of viscosity has a long history, dating back to the 17th century, when Isaak Newton (16431727) provided a qualitative description of viscosity in his 1687 publication Philosophi Naturalis Principia Mathematica as the lack of slipperiness of the parts of the liquid reflecting internal friction of fluids and developed a formal description of the relation between the shear stress of fluid and its flow rate (Newton, 1687)

It is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered