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Evidence from experimental and clinical studies Preclinical data Animal studies have demonstrated that chronic exposure to e-cigarette vapor induces hepatic triglyceride accumulation and lipid droplet formation, hallmark features of MASLD [133]

In its capacity as DAMPs, HMGB1 can promote the aggregation of neutrophils at sites of tissue damage and enhance inflammatory responses via interaction with other DAMPs (such as DNA) or pathogen-associated molecular patterns (PAMPs) (such as lipopolysaccharide (LPS))

Bobylev I, Joshi Abhijeet R, Barham M et al (2018) Depletion of mitofusin-2 causes mitochondrial damage in cisplatin-induced neuropathy

It is a pro-oxidant, enhancing the accumulation of lipid peroxidation products