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In high-grade dysplasia (HGD), there are marked cytologic changes (Figure 3): enlarged, hyperchromatic, and pleomorphic nuclei with at least focal loss of polarity, increased and atypical mitosis, and crowding of glands with almost complete loss of lamina propria

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The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production

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