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Why people love it: Skin that feels firmer and smoother

Individual results may vary based on skin type, lifestyle, and genetics

Numerous signaling pathways, such as cyclooxygenase 2 (COX-2), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) signaling, phosphoinositide 3 kinase (PI3K), and the GATA4/p62-mediated autophagy pathways result in the stimulation of NF-B and/or C/EBP pathways, which in turn regulate the SASP secretome (81, 82)

However, by improving sleep quality, supporting recovery, and optimizing growth hormone levels, sermorelin may create conditions that indirectly support healthier overall hormonal balance