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All raw data were initially subjected to a normal distribution and analysis by one-sample KolmogorovSmirnov (K-S) nonparametric test using SPSS 22.0 software, and results confirmed that all data conformed to a normal distribution, thus parametric tests were applied

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The most common side effects are gastrointestinal, including nausea, vomiting, diarrhea, and decreased appetite

The emergence of these secondary messenger molecules, particularly IP3, may stimulate the release of calcium ions (Ca2+) from the cells internal reserves