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Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

In our study, we used higher concentration of TA (500 mg/5 ml) and observed that on right cheek, there was significant reduction in VAS score from baseline to 8th week and baseline to 12th week, suggesting that TA was more effective in treatment of facial melasma

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134 This test is based on the fluorescence of NADPH, after glucose-6-phosphate and NADP are added to a hemolysate of test cells