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Although this mechanism by which zonulin dysregulates tight junctions has been well described thus far, it is important to note the controversy around EGFR localization within the apical membrane of intestinal epithelial cells and the implications this controversy may have on this specific mechanism

10.1053/gg.2000.5925 Gastroenterology 39 DubinskyM

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When paired with medications, these tools can offer real-time coaching, behavioral tracking, and contingency management, in addition to psychoeducational curriculum and evidence-based therapies delivered immediately when a client most needs support