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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

Instead, you begin low and increase gradually over weeks, giving your body time to adjust and minimizing the gastrointestinal side effects that come with GLP-1 receptor activation

10.1016/j.ejmech.2017.11.057 32 KaravolosS.ReynoldsM.PanagiotopoulouN.McElenyK.ScallyM.QuintonR