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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

The peptide accelerates regeneration of intestinal mucosa and submucosa, restores tight junction proteins (claudin-1, occludin, ZO-1) that fail in intestinal permeability syndromes, and increases local blood supply through VEGF-mediated angiogenesis

The clinical applications of IGF-1 LR3 span across various growth deficiencies and conditions requiring anabolic support, including hormone deficiencies leading to short stature, Turner Syndrome, muscle-wasting diseases, and conditions associated with pituitary tumors