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These non-genomic signals are mediated by membrane-associated receptors and can rapidly activate pathways such as extracellular signal-regulated kinase)/mitogen-activated protein kinase, protein kinase C (elevating intracellular Ca 2+ ), JNK/phosphatidylinositol 3 kinase, and cAMP-dependent transcription, which regulate critical cellular processes including apoptosis

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One of the limitations of BBB models prepared from stem cell derived vascular endothelial cells is to induce appropriate barrier tightness and BBB characteristics