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Folic acid, which is the form found in fortified foods and supplements is also a poor substrate for folylpolyglutamate synthase accounting for its efficient uptake from the intestines and release to the blood

This method ensures a more efficient and rapid absorption of the substances into the bloodstream, allowing for immediate therapeutic effects

As a result, the systemic exposure to the unconjugated form is typically low and highly sensitive to individual differences in metabolic enzyme activity (e.g., UGTs and SULTs), leading to marked inter-individual variability

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