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Their findings included sleep effects at 25 mcg/kg IV in rabbits and preferential REM augmentation at 25 mcg/kg IV in cats

in fact, an estimated 95% is thought to be reabsorbed by the kidneys (1)

In general, we recommend following the recommendations in the 1 H MRS methodology consensus statements cited in section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS