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In diabetes, hyperglycemia is the primary factor that produces complexities for a long time, including cardiovascular disease, diabetic neuropathy, retinopathy, immune dysfunction, and pulmonary disorder

Inappropriate iron supplementation or excessive intake of iron supplements often leads to ROS accumulation through the Fenton and Haber-Weiss reactions, triggering oxidative stress, LPO, damage to intestinal epithelial cells, and even cell death, which disrupts the intestinal mucosal barrier function

It was reported that STK40, a pseudokinase functions as a COP1 adaptor to modulate c-Jun protein levels 49