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Further evaluation: If the acute onset of unilateral or flank pain, severe abdominal pain, abdominal tenderness bilious vomiting, perform ALT/GGT (LFT's), lipase amylase, an abdominal and pelvic ultrasound to exclude e.g., gallstones or acute hydronephrosis should be performed (132)

Likewise, during liver fibrosis, hepatic stellate cells (HSC) stimulated by TGF- induced palmitoylation of hexokinase 1 (HK1) and secretion through large EVs in a TSG101-dependent manner

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Their antioxidative properties stem from neutralizing ROS via direct radical scavenging or by enhancing endogenous antioxidant defense mechanisms, such as the Nrf2 pathway, reducing oxidative cellular damage 189