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Further Nrf2 translocates into the nucleus, heterodimerizes with one of the small musculo-aponeurotic fibrosarcoma (sMaf) proteins, binds to the antioxidant responsive element (ARE) or electrophile responsive element (EpRE) and promotes the transcription of genes encoding defense proteins/enzymes (Yamamoto et al., 2018)

Torsemide versus furosemide in patients with acute heart failure (from the ASCEND-HF trial)

Moreover, CD147 can directly enhance the angiogenic capacity of endothelial cells by upregulating hypoxia-inducible factor 2 alpha (HIF-2), vascular endothelial growth factor receptor 2 (VEGFR-2), and soluble VEGF isoforms

H., Petrovic, A.,