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doi: 10.1016/j.etap.2014.04.017, PMID: [DOI] [PubMed] [Google Scholar] 451

We conducted a wide range of additional control experiments to make sure we were looking at a true Orai1 deficiency phenotype. The investigators also created genetically modified mice that lacked Orai1 channels in excitatory neurons, but retained them elsewhere in the body and the brain

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Erastin is a synthetic drug that induces cell death through ferroptosis in tumor cells bearing mutant RAS by increasing intracellular ROS levels and altering the permeability of the outer mitochondrial membrane 130,131