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Experimental design considerations include the importance of timing senolytic administration relative to senescence induction or disease progression, as the biological context affects both efficacy and interpretation of results

Similar cytoplasmic inclusions induced by phenobarbital have been reported in dogs (Ito et al

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This review highlights the therapeutic potential of individual natural compounds, as well as emerging strategies in combinatorial and precision medicine, offering a comprehensive synthesis of current advancements in natural product-based AD therapy