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While semaglutide activates one receptor (GLP-1) and tirzepatide activates two (GLP-1 and GIP), retatrutide activates three: GLP-1, GIP, and glucagon receptors simultaneously

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These proteins have a substantial influence on the multifaceted functions of nearly all cellular processes

The researchers concluded that GLP-1 therapy for obesity should include resistance training, optimal protein intake, and if needed, specific nutrients and pharmacological interventions to preserve muscle mass