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This system effectively reversed the immunosuppressive state by promoting the polarization of tumor-associated macrophages from the M2 phenotype to the M1 phenotype

L-cysteine Supplementation Increases Blood Levels of Hydrogen Sulfide and Nitrite, and Decreases Insulin Resistance and Vascular Inflammation in Zucker Diabetic Rats

Biomed Pharmacother 93:646653 Ansari MA, Raish M, Ahmad A, Ahmad SF, Mudassar S, Mohsin K (2016) Sinapic acid mitigates gentamicin-induced nephrotoxicity and associated oxidative/nitrosative stress, apoptosis, and inflammation in rats

The standard treatment to prevent deficiency for these patients is vitamin B12 injections, lifelong, every 3 months