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For patients who have exhausted conventional sleep interventions (sleep hygiene, CBT-I, conventional medications) and remain symptomatic, DSIP represents a speculative option with a plausible mechanism

The theoretical concern around HGF/c-Met-mediated cellular growth means medical monitoring is particularly important

Once pathological aetiologias have been discarded, it is relevant to question the supply and status of vitamins and minerals and to provide nutritional advice first aiming at promoting balanced food choices, then focusing on the use of vitamin and mineral supplementation